Pediatric Pulmonology

BackgroundAsthma is a frequent comorbidity in children with sickle cell disease and has been associated with an increased risk of acute complications, particularly vaso-occlusive crises and acute chest syndrome. However, determinants of clinical severity among children with sickle cell disease and confirmed asthma remain poorly characterized, especially in tropical settings. This study aimed to identify factors associated with clinical severity in this population. MethodsWe conducted an observational study among children with sickle cell disease followed in French Guiana. The analysis was restricted to children with confirmed asthma. Clinical severity was defined as the occurrence of at least two hospitalizations during the 12 months preceding evaluation for vaso-occlusive crises and/or acute chest syndrome. Factors associated with severity were assessed using univariate and multivariate logistic regression analyses. ResultsA total of 138 children with sickle cell disease and confirmed asthma were included, of whom 49 (35.5%) presented a severe clinical form. In multivariate analysis, no variable was independently associated with clinical severity. However, a trend toward an increased risk of severe disease was observed among children living in rural areas (adjusted OR = 1.94; 95% CI: 0.77-4.86), while a trend toward a protective effect was observed for Strongyloides stercoralis infection (adjusted OR = 0.18; 95% CI: 0.02-1.51). Allergic sensitization, although frequent (64.5%), was not associated with clinical severity after adjustment (adjusted OR = 0.66; 95% CI: 0.31-1.44). ConclusionAmong children with sickle cell disease and confirmed asthma, more than one third experience severe clinical disease. Severity does not appear to be driven by allergy but may be influenced by environmental and contextual factors specific to tropical settings. These findings support a stratified approach to sickle cell-associated asthma to identify high-risk children and prevent avoidable acute complications.

Pediatric asthma exacerbations are a frequent cause of emergency department (ED) visits and hospitalizations, yet accurate risk prediction remains limited and no consensus risk scores exist. Using UF Health electronic health records (EHRs) from 2011-2023, we evaluated two computable phenotypes (i.e., CAPriCORN and COMPAC) to predict exacerbations over 6-, 12-, and 24-month horizons. Exacerbations were defined using a validated composite of diagnosis codes from ED, inpatient, or outpatient encounters combined with systemic corticosteroids prescriptions. Several commonly used machine learning (ML) models were trained with stratified five-fold cross-validation, Bayesian hyperparameter optimization, and Youdens J thresholding. XGBoost achieved the best performance, with SHapley Additive exPlanations (SHAP) highlighting note-derived symptom terms and rescue-medication use as dominant predictors. Future work will focus on external validation and assessment of generalizability. This interpretable, text-integrated framework may support child-specific risk stratification and inform EHR-based decision support for timely pediatric asthma management.

BackgroundPediatric eczema is a highly prevalent condition that often causes substantial suffering among affected children and their families. Numerous modifiable lifestyle and environmental risk factors for the condition have been identified, although these risk factors and related interventions have generally been studied in isolation. The goal of this study was to evaluate the effects of an integrative program for parents of children with eczema that simultaneously addressed multiple lifestyle and environmental risk factors. MethodsChildren with eczema diagnosis who began the online eczema program and provided outcomes data from May 2024 to May 2025 were eligible. The primary outcome was the Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD), a validated measure of eczema symptoms and burden. Outcomes were assessed at baseline and at one month, two months, and six months after beginning the program. Changes in mean PO-SCORAD scores from baseline throughout the duration of the study were assessed with analysis of variance (ANOVA). Multivariate linear regression modeling of PO-SCORAD scores using population-averaged generalized estimating equations (GEE) were also constructed accounting for baseline PO-SCORAD scores and adjusting for age, sex, presence of any allergy, use of topical corticosteroids, and use of antihistamines. Results197 participants were included in the study. The mean baseline PO-SCORAD score was 51.4, which is considered severe eczema. PO-SCORAD scores improved over the course of the study (p<0.0001) and there were statistically significant and clinically meaningful improvements noted after one month (11.3 points, 22.0% improvement), two months (17.8 points, 34.6% improvement), and six months (27.2 points, 52.9% improvement) in the program (p<0.0001). After accounting for baseline PO-SCORAD scores and covariates in regression modeling, there was a 22.5-point (p<0.0001) improvement in PO-SCORAD scores from baseline to final assessment. There was a 31.4-point decrease in PO-SCORAD scores from baseline to final assessment (p<0.0001, 47.2% improvement) among the subgroup of participants with severe eczema symptoms at baseline. ConclusionsAn online program focusing on modifiable lifestyle and environmental modifications was associated with clinically meaningful symptom improvements among children with eczema. Symptoms improved relatively quickly and the greatest improvements were noted among children with severe symptoms at baseline.

BackgroundQuality of life (QoL), the highest prioritised outcome by children with bronchiectasis and their parents, is a patient-reported outcome measure increasingly considered essential when evaluating health and interventions. Despite this, there are no validated instruments that specifically measure QoL related to bronchiectasis in children. We aimed to develop and validate a new bronchiectasis child-specific parent-proxy QoL instrument (BC-QoL). MethodsWe developed a draft 44-item BC-QoL and subsequently conducted a prospective cohort study where 142 parents completed draft BC-QoL and six other measures: two validated cough scores, parent-proxy childrens acute cough-specific QoL, depression, anxiety and stress 21-item scale, RAND-36 and paediatric QoL (PedsQLTM4.0) to assess the convergent and discriminant validity of the BC-QoL. The questionnaires were completed over three weeks at different phases of their childs illness (stable state, exacerbation and/or recovery). Responses were analysed using psychometric and clinical impact techniques to reduce items and determine the instruments reliability and validity. Minimally important difference (MID) was also calculated. ResultsThe final 23-item BC-QoL instrument with its three domains (emotional, physical, social well-being) demonstrated high split half reliability (0.95), Cronbachs alpha (0.97), repeatability (intraclass coefficient=0.74, 95%CI 0.62-0.82), validity and responsiveness. BC-QoLs domains significantly correlated with that of PedsQLTM4.0 (Spearman correlations: emotional=0.43, social=0.41, physical=0.47). BC-QoLs MID ranged from 0.74 to 1.32. ConclusionBC-QoL, the first bronchiectasis child-specific QoL instrument, has evidence demonstrating its validity and reliability, and can be used to evaluate the impact and effectiveness of interventions and better understand the disease burden in children with bronchiectasis.

BackgroundImpulse oscillometry is a noninvasive pulmonary function test performed during quiet breathing and requires minimal patient cooperation. It is useful for detecting small airway disease and provides increased sensitivity for diagnosing asthma in younger children who may have difficulty completing standard spirometry. Bronchodilator testing, a standard assessment of airflow obstruction reversibility, is recommended in patients with suspected asthma who present obstructive airflow patterns. ObjectiveTo evaluate impulse oscillometry parameters before and after bronchodilator administration across different age groups and to examine the relationship between age and airway resistance in patients with clinician-diagnosed asthma. MethodsThis retrospective study included patients with clinician-diagnosed asthma who demonstrated obstructive airflow patterns and a positive bronchodilator response. Participants were grouped by age: younger than 6 years, 6 to 20 years, and older than 20 years. Key impulse oscillometry parameters--airway resistance at 5 Hz, airway resistance at 20 Hz, the difference between these values, and resonance frequency--were collected and compared across groups. A positive bronchodilator response was defined as a reduction in airway resistance of more than 30% in individuals younger than 18 years and more than 40% in adults. ResultsA total of 225 patients (123 males and 102 females) were included, with a median age of 6 years. At baseline, the median airway resistance at 5 Hz was 175.34% of the reference value (95% CI, 171.66-178.62), and airway resistance at 20 Hz was 121.68% (95% CI, 118.73-127.12). The median difference between these values was 52.32% (95% CI, 49.89-57.14), and the median resonance frequency was 5.11 Hz (95% CI, 4.62-5.35). After bronchodilator administration, airway resistance at 5 Hz decreased to 123.56% (95% CI, 119.07-126.77), corresponding to a median reduction of 52.8% (95% CI, 49.48-56.08; P < 0.0001). Age demonstrated a moderate positive correlation with airway resistance at 20 Hz (r = 0.51, P < 0.001). ConclusionsProximal airway resistance increases with age among patients with asthma, suggesting age-related differences in airway inflammation. Impulse oscillometry combined with bronchodilator assessment provides a practical approach for evaluating airflow reversibility and enhances diagnostic accuracy in suspected asthma.

IntroductionChildhood asthma remains a major public health challenge in low- and middle-income countries, where social and economic factors influence disease outcomes. This study examined the sociodemographic determinants of asthma exacerbation among children attending clinic at Thika Level 5 Hospital, Kenya. MethodsThis study employed a hospital-based cross-sectional study involving 108 caregivers- child dyads, each consisting of a child with confirmed asthma and their primary caregiver. The dyads were recruited from the pediatric asthma clinic from 31st March 2025 to 30th April 2025 then follow up was conducted for six months form 1st May to 31st October 2025. Data were collected using structured questionnaires and clinic records. Descriptive statistics summarized sociodemographic characteristics, while chi-square tests and logistic regression assessed associations between caregiver factors and asthma control. ResultsThe mean age of children was 8.1 years (range 3-17), with males comprising 57.4%. Most caregivers were mothers (88%), had secondary education (57.4%), and were in informal employment (75.9%). Household income was low for 59.3% of participants (<KES 30,000/month). Caregiver education (AOR=2.8; 95% CI:1.5-5.2; p=0.001) was the strongest predictor of asthma control, followed by medical insurance ({chi}2=10.41; p=0.001). Formal employment and higher income were significantly associated with controlled asthma ({chi}2=6.45; p=0.04 and {chi}2=9.72; p=0.02 respectively). Urban residence modified the positive effect of education on asthma management (interaction AOR=1.9; p=0.03). ConclusionCaregiver education level, employment, income, and medical insurance significantly influence asthma control among children. Enhancing health literacy and expanding insurance coverage under the Social Health Authority (SHA) can improve asthma outcomes in Kenyan children.

BackgroundChildren with tracheostomies experience frequent and recurrent acute respiratory infections (ARIs). While cultured respiratory pathogens can inform ARI diagnosis, it is unknown if their presence in the airway affects future ARI risk. ObjectiveTo identify predictors of frequent (3+) ARIs within 36 months of tracheostomy. MethodsWe conducted a single-center, retrospective cohort study of children with tracheostomies placed between 2010-2016. Medical records were reviewed for each encounter in which a respiratory culture was obtained over the 3 years post-tracheostomy. ARIs were defined using encounter ICD-9/10 codes. Logistic and Poisson regression were used to model the association between clinical and microbiologic predictor variables with having frequent (3+) ARIs and the total number of ARIs per child. Mediation analysis using stepwise regression models further evaluated the role of P. aeruginosa. ResultsAmong 436 children, 631 diagnosed ARIs occurred within 36 months of tracheostomy; 20.2% of children had 3+ ARIs. Pseudomonas aeruginosa was isolated in 25% of children and was more common among those with 3+ ARIs compared with 0-2 ARIs (56.8% vs 20.7%, p<0.001). Those with early P. aeruginosa isolation were more likely to have 3+ ARIs (aOR 3.38, 95% CI 1.97-5.81), and this relationship persisted when analyzing ARIs and P. aeruginosa counts. Identification of P. aeruginosa partially mediated the relationship of ventilator dependence with ARI frequency. ConclusionIsolation of P. aeruginosa, particularly early and repeated isolation, is associated with frequent ARIs in the 3 years after tracheostomy and is an important partial mediator. Findings may inform risk stratification and targeted treatment strategies.

ObjectivesVentilator-associated pneumonia (VAP) is a significant complication in pediatric patients with severe bronchiolitis undergoing mechanical ventilation (MV) in pediatric intensive care units (PICUs). The role of respiratory microbiota in VAP development remains underexplored in this vulnerable population. This study aimed to characterize respiratory microbiota in critically ill children with severe bronchiolitis receiving critical care and identify microbial patterns associated with VAP. MethodsWe conducted a cohort study in paediatric patients with severe bronchiolitis requiring MV at a tertiary PICU in Catalonia, Spain. Epidemiological, clinical and microbiological data were collected. Respiratory microbiota was assessed using 16S rRNA gene sequencing of nasopharyngeal (NP) aspirates and bronchoalveolar lavage (BAL) samples obtained before and during MV. ResultsBaseline NP microbiota differed significantly between VAP and non-VAP groups, with overrepresentation of Moraxella, Enterobacter, and Amniculibacterium genera and underrepresentation of Prevotella in patients who developed VAP. BAL microbiota showed fewer differences, although Enterobacter was more abundant in VAP cases. Random forest models demonstrated strong predictive performance, with the model integrating NP microbiota and clinical parameters achieving the highest accuracy (AUC 0.956). ConclusionsSpecific nasopharyngeal microbial signatures, combined with clinical factors, may serve as risk markers for VAP in mechanically ventilated children, potentially guiding targeted prevention strategies in PICUs.

BackgroundPediatric long COVID is associated with substantial symptom burden, yet evidence-based pharmacologic treatments remain limited. Low-dose naltrexone (LDN) has been proposed as a potential symptomatic therapy, but data in pediatric populations is lacking. MethodsWe conducted a retrospective analysis of pediatric and young adult patients ([&le;]25 years) with a clinical diagnosis of long COVID who were prescribed LDN between July 2020 and July 2025 at three multidisciplinary pediatric long COVID programs in the United States. Deidentified clinical data were extracted from medical records. Outcomes included symptom prevalence, dosing practices, treatment continuation or discontinuation, adverse effects, and available patient-reported quality-of-life measures (PedsQL and PROMIS(R)). FindingsThe study included 62 patients (mean age, 15.6 years [range, 8-23]; 53.2% male and 46.8% female). Fatigue was nearly universal (98.4%), followed by headaches (87.1%), brain fog (74.2%), dizziness/lightheadedness (67.7%), anxiety (66.1%), and post-exertional malaise (56.5%). LDN-treated patients demonstrated a higher prevalence of neurocognitive and autonomic symptoms, compared to general clinic cohorts. Most patients (71.0%) reported no adverse effects; the most common were vivid dreams (9.7%) and insomnia (9.7%). At follow-up, 66.1% of patients remained on LDN. Medication discontinuation was attributed to perceived lack of benefit (43.8%) or side effects (25.0%). Baseline quality-of-life measures at initiation showed marked impairment: PedsQL Physical Health (M=38.0, SD=20.9) and Multidimensional Fatigue (M=35.7, SD=15.8) scores were low. PROMIS scores indicated reduced physical functioning (M=36.8, SD=8.7) and cognitive functioning (M=40.8, SD=7.6), with elevated fatigue (M=68.0, SD=10.4) and pain interference (M=58.6, SD=8.2) relative to population norms. The study was not designed to assess efficacy. InterpretationLDN was primarily prescribed to patients with prominent fatigue, neurocognitive symptoms, and autonomic dysfunction, and was generally well tolerated. These findings provide descriptive evidence of real-world prescribing practices and support the need for clinical trials to systematically evaluate LDNs efficacy in pediatric long COVID.

The genetic relationship between asthma and lung function may be dependent on age-at-onset (AAO) of asthma. We investigated whether the shared genetics between asthma AAO and lung function is dependent on AAO. Asthma cases from UK Biobank were subset according to their AAO and genetic correlation was used to obtain genetically homogeneous groups, i.e., [&le;]20 (LT20), 20-40, and >40 (GT40) years. Association analysis and fine-mapping were performed to identify shared genetics between AAO groups and lung function. Mediation and quantitative trait locus (QTL) analyses were performed to identify mechanisms underlying shared genetic associations. Chr5, chr6, chr12, and chr17 each had one region that displayed a cross-phenotype replicated association with at least one AAO group and lung function. Overlapping credible sets obtained from fine-mapping were observed on chr5 and chr6. Mediation analyses demonstrated that for each region the proportion mediated through asthma on lung function was larger for asthma LT20 compared to 20-40 and GT40 suggesting that their effects on lung function were more strongly driven by this association. Tissue-specific QTL analysis revealed shared etiology on chr5 may be acting through SLC22A5 and C5orf56 which might play an important role in decreased lung function among individuals with earlier-onset asthma.

ObjectiveOrofacial clefts may involve the complete vertical thickness of the lip (complete) or partial thickness (incomplete). This study evaluates side preference for completeness in nonsyndromic asymmetric bilateral and unilateral cleft lip with or without cleft palate (NSCL/P). DesignWe studied 4 multiethnic cohorts from North and South America, Asia, and Africa, including 3,561 individuals with NSCL/P. Associations between cleft completeness, sex, ethnicity, and race were assessed using Chi-square or Fishers exact test (=0.05). ParticipantsPatients with NSCL/P with complete information on cleft type and completeness were included. Our main goal was to analyze side preference of complete clefting in different demographic groups, sex and race. ResultsAmongst asymmetric bilateral cases, left side completeness was significantly more frequent than the right side (73.7% vs. 26.3%; p<0.001). No associations observed for sex or race with ethnicity showing a trend toward significance (50.0% vs. 25.5%; p=0.088). Amongst symmetric bilateral and unilateral cases, Hispanics exhibited completeness more frequently than non-Hispanics (96.4% vs 89.5%; p<0.001; 84.1% vs. 79.7%; p<0.001). For unilateral cases, completeness showed no side preference. Caucasians were less likely to exhibit complete clefts compared to Asians, Blacks, or other racial groups (68.7% vs 84.9% or 81.2% or 81.7%; p<0.001). Females more frequently presented with completeness than males (81.2% vs 76.6%; p=0.003). ConclusionsIn NSCL/P with bilateral asymmetry, the left side is more often complete than the right side. Although unilateral left-sided clefts are more common overall, completeness shows no side preference. Race and ethnicity demonstrate significant associations with cleft severity patterns.

IntroductionCentral line-associated bloodstream-infection (CLA-BSI) and catheter-related bloodstream infections (CR-BSI) remain a significant concern in pediatric inpatient units. ObjectiveTo analyze a case series of CLA-BSI and CR-BSI in hospitalized pediatric patients in hospitals with rigorous infection prevention measures. Materials and MethodsThis was an analytical, descriptive, and retrospective study conducted in patients aged 0 to 18 years, admitted between August 2023 and March 2025, with a diagnosis of CLA-BSI or CR-BSI in two pediatric hospitals in Rio de Janeiro, Brazil. Variables potentially associated with the occurrence of infection were analyzed. ResultsA total of 86 infections were evaluated, comprising 66 CLA-BSI and 20 CR-BSI. Sixty patients (69.8%) were male, with a mean age of 71.8 months. Sixty-five (83.7%) had previous comorbidities, 63 (73.2%) had a prior hospitalization, and 27 (31.4%) had another invasive device. The mean time from catheter insertion to infection diagnosis was 32.1 days, and the mean time from hospital admission to infection onset was 18.45 days. Gram-negative bacteria were isolated in 40/86 (46.5%) cases. At 30 days post-infection, 61/86 (70.9%) had been discharged, 20/86 (23.3%) remained hospitalized, and 5/86 (5.8%) had died. There was no correlation between the bacterial group and the type of catheter used (p=0.068), nor between infection type (CLA-BSI vs. CR-BSI) and mortality outcome (p=1). ConclusionsCLA-BSI and CR-BSI occurred predominantly in patients with prolonged hospital stays and underlying comorbidities, and were mainly caused by Gram-negative bacteria.

The ERS/ATS22 interpretative flowchart classifies diffusing capacity (DLco) into 5 scenarios with associated pathophysiology, and has not been tested on large patient groups. We aimed to obtain a more layered DLco interpretation, by interrogating DLco components Kco and VA, and by estimating lung inflation during the DLco test to identify the presence of restriction, which crucially impacts Kco interpretation. By assessing a "low VA" against lung inflation, a novel 9-scenario DLco classification with associated pathophysiology can be obtained. Lung patients from a tertiary center were classified according to the ERS/ATS22 chart and the novel 9-scenario one. Besides a control group of healthy subjects (n=303), disease groups under study were the following : asthma (n=1615), COPD (n=1338), CF (n=108), extrapulmonary restriction (n=122), ILD (n=98), post-COVID (n=193). Except for COPD, the prevalence of "normal DLco" (ERS/ATS22) was generally greater than that of "normal VA and normal Kco" (9-scenario); this discrepancy was most marked in CF (81% vs 56%) and in extrapulmonary restriction (57% vs 37%). With the novel 9-scenario chart, patients from very different diagnostic groups with a "low DLco" due to emphysema, bronchial disease, interstitial damage or incomplete expansion got classified across distinct scenarios, whereas ERS/ATS22 just grouped them together. In conclusion, when "low VA" is evaluated against lung inflation, a differentiation of DLco interpretation can be obtained in various patient groups involving obstruction and/or restriction. This approach can be readily implemented in clinical practice.

BackgroundBronchiectasis is a debilitating respiratory condition characterized by chronic cough with expectoration of thick sputum. It accounts for significant morbidity and mortality, especially when associated with exacerbations. Assessing the health-related quality of life (HR-QoL) of patients with bronchiectasis is important to ascertain the impact of the disease on day-to-day life, as well as to gauge the effect of targeted interventions. Conventionally used methods for assessing HR-QoL such as the St. Georges Respiratory Questionnaire (SGRQ) are time-consuming and have limitations in day-to-day application. The Bronchiectasis Health Questionnaire (BHQ) is a novel, compact tool used for assessing the HR-QoL, and has been validated for use in Korean and Turkish populations. MethodsWe attempted to develop and validate the Hindi version of the Bronchiectasis Health Questionnaire (BHQ) in Indian adults with bronchiectasis. We assessed the correlation between the Hindi BHQ (H-BHQ) scores and other measures of lung health including the Hindi version of the COPD Assessment Tool (H-CAT), pulmonary function tests and the bronchiectasis severity index (BSI). In addition, we assessed the correlation between the H-BHQ scores and the number of exacerbations and hospital admissions in the previous year. ResultsA total of 145 subjects with bronchiectasis were included. The mean ({+/-} SD) H-BHQ total score was 49.10 {+/-} 10.3. The H-BHQ score correlated well with the H-CAT score (Correlation coefficient -0.6534, p value < 0.0001) and the mMRC scale (Correlation coefficient of -0.4459,p value < 0.0001). The H-BHQ score also had a moderate correlation with the number of exacerbations and low correlation with hospital admissions in the previous year, with correlation coefficients of -0.4193 (p < 0.0001) and -0.3030 (p < 0.0001), respectively. The correlation between the H-BHQ and the Bronchiectasis Severity Index (BSI) score was weak (Correlation coefficient of -0.3012, p value < 0.01). ConclusionThe H-BHQ offers a simple and convenient method to assess the HR-QoL in patients with bronchiectasis, and correlates well with other measures of respiratory health, including the H-CAT, the mMRC score and the number of exacerbations and hospital admissions in the previous year.

IntroductionThe circadian clock is an internal, [~]24-hour biological timer that synchronizes physiology with the day-night cycle. Social jetlag (SJL) describes the misalignment between this internal clock and social schedules, a condition affecting approximately 70% of the population and linked to a spectrum of metabolic, mental, and cognitive health issues. This study examined how the 2022 FIFA World Cup disrupted normal childrens sleep routines and other associated factors from parents prospect. MethodsAn online, cross-sectional survey was distributed to parents (N=848). The questionnaire collected sociodemographic data, childrens habitual sleep habits, and changes perceived during the 2022 FIFA World Cup. SJL was defined as a [&ge;]1-hour delay in bedtime on weekends versus weekdays. Multivariable logistic regression analyses identified factors associated with perceived sleep changes and SJL. ResultsOver half (53.4%) of the children exhibited pre-existing weekend SJL. Children aged 5-11 (OR=1.847, p<0.001), higher socioeconomic status (OR=1.383, p<0.001), international residency (OR=2.845, p<0.001) were significant predictors of baseline weekend SJL. During the tournament, 33% and 17.8% of parents reported their children had delayed sleep ([&ge;]1 hour) on weekdays and weekends due to match watching, respectively. Regression analysis revealed that these parental perceived FIFA impact on their children sleep was significantly associated with weekdays SJL OR= 1.958, p=0.001 and weekends OR= 1.784, p=0.009 during the FIFIA season. DiscussionOur findings indicate that major social events can exacerbate circadian misalignment and SJL, likely driven by social conformation. The high prevalence of baseline SL confirms it is a widespread pediatric health issue. The vulnerability of the 5-11 age group shows SJL is not exclusively an adolescent problem. ConclusionMajor sporting events significantly disrupt childrens sleep schedules, compounding the public health issue of chronic SJL. Proactive guidance for families is needed during such events. More importantly, these findings underscore the urgent need for structural changes to align social schedules with pediatric circadian biology.

Malnutrition is a deficiency of both macro- and micro-nutrients. Malnutrition is common in children with congenital heart defects due to reduced intake, poor gastrointestinal absorption resulting from gut hypo-perfusion and increased metabolism. The present study aimed to determine the prevalence and predictors of hypovitaminosis D in children with congenital heart defects aged 1 to 12 years compared with apparently healthy controls. MethodsA comparative cross-sectional study conducted from July to November 2020 involving 115 children with congenital heart disease and 115 apparently healthy controls matched for age, sex and socio-economic class. A self-designed proforma was used to collect information on subjects bio-data, socio-economic class, health information, morbidity pattern, frequency and duration of sunlight exposure and 48 hours dietary recall of vitamin D containing foods. Weight, height, waist and hip circumference were measured, BMI was calculated, waist hip ratio, weight-for-age, height-for-age and BMI-for-age Z scores were obtained. Blood samples were collected for measurement of serum 25-hydroxyvitamin D levels. Hypovitaminosis D was taken as both vitamin D deficiency and insufficiency with serum 25(OH)D levels of less than 20ng/ml and 20.1-29.9ng/ml respectively. Descriptive and inferential analysis was carried out using SPSS version 27. ResultThe prevalence of hypovitaminosis D in subjects was 59.1% with median (interquartile range) of 28.13ng/ml (21.2-42.3ng/ml) while the prevalence in healthy controls was 41.7%. The difference was statistically significant (p= 0.008). There was no statistically significant difference in the prevalence of hypovitaminosis D between the acyanotic and cyanotic subjects. The age groups greater than 3 years, female sex and duration of diagnosis greater than 48 months were independent predictors of hypovitaminosis D in subjects. Conclusionchildren with congenital heart defect should have their serum 25-hydroxyvitamin D measured at intervals and may benefit from treatment if found to have vitamin D deficiency.

ImportanceGlucocorticoid steroids are increasingly prescribed during the periconceptual period with the hypothesis that they reduce intrauterine inflammation and improve pregnancy rates. There is no robust evidence to support this practice, and the potential harm has not been well characterised. ObjectiveTo examine the risk of adverse perinatal outcomes associated with non-medically indicated glucocorticoid steroid use during the periconceptual period. DesignPopulation-wide linked retrospective cohort study. SettingVictoria, Australia. ParticipantsAfter excluding women with medical indications for steroid use (autoimmune disease, chronic asthma and previous organ transplant), our total cohort included 805,353 births between 2009 and 2021. ExposurePrescriptions of glucocorticoid steroids dispensed during the periconceptual period (12 weeks prior to conception - end of first trimester). Main Outcome(s) and Measure(s)Four primary outcomes were examined - spontaneous preterm birth before 37 completed weeks gestation, small for gestational age (<10th birthweight centile), major congenital abnormality and perinatal mortality. A doubly robust inverse probability weighted regression adjustment model was used to estimate the association between glucocorticoid steroid exposure and outcomes and presented as adjusted relative risks (aRR) with corresponding 95% confidence intervals (95% CI). ResultsThere were 12,301 (1.5%) pregnancies exposed to glucocorticoid steroids during the periconceptual period and 793,052 unexposed. Among the steroid-exposed cohort, major congenital abnormalities occurred in 4.5% of pregnancies, compared with 3.5% among those unexposed to steroids. This resulted in a 23% increased risk of major congenital abnormality (aRR 1.23, 95%CI 1.13-1.34). There were no significant associations between steroid exposure and spontaneous preterm birth (2.4 vs 2.5%; aRR 1.05, 95%CI 0.93-1.19), small for gestational age neonates (9.4 vs 9.3%; aRR 1.02, 95%CI 0.97-1.07) or perinatal mortality (0.5 vs 0.7%; aRR 1.05, 95%CI 0.87-1.26). Conclusions and RelevanceIn our cohort, periconceptual steroid exposure was associated with an increased risk of major congenital abnormality. In the absence of clear clinical indications, avoiding the prescription of periconceptual steroids is critically important. KEY POINTSO_ST_ABSQuestionC_ST_ABSWhat are the risks of adverse perinatal outcomes among patients prescribed glucocorticoid steroids during the periconceptual period? FindingsPericonceptual steroid use is associated with an increased risk of major congenital abnormality. MeaningIn the absence of an indication, periconceptual steroid use does not have clear evidence of benefit, there is now also evidence of significant harm and this practice should not be recommended.

IntroductionPediatric acute appendicitis (PAA) remains challenging to diagnose despite existing diagnostic scores. The BIDIAP index is a three-item diagnostic tool with very high discriminative performance in a derivation cohort. This study aimed to prospectively and externally validate the BIDIAP index in a multicenter pediatric population. Material and MethodsWe conducted a prospective, multicenter observational study across four tertiary pediatric centers, enrolling children presenting with suspected PAA. Two groups were analyzed: patients with histopathologically confirmed PAA and patients in whom appendicitis was confidently excluded after diagnostic work-up, classified as non-surgical abdominal pain (NSAP). The BIDIAP index was applied using a predefined cutoff ([&ge;] 4 points), and diagnostic performance was assessed using ROC analysis, calibration metrics, and decision curve analysis (DCA). ResultsA total of 644 patients meeting the prespecified analytical criteria were included in the primary analysis. The BIDIAP index demonstrated excellent diagnostic performance, with an area under the ROC curve of 0.93 (95% CI, 0.92-0.95). The calibration slope was 1.00, and the intercept was close to zero, indicating close agreement between predicted and observed risks. At the prespecified cutoff value of [&ge;] 4 points, the BIDIAP index achieved a sensitivity of 90.5% and a specificity of 81.6%. DCA showed a positive net clinical benefit of the BIDIAP index over treat-all and treat-none strategies across the full range of clinically relevant threshold probabilities. ConclusionsThe BIDIAP index demonstrated excellent diagnostic performance for PAA. Its simplicity, based on only three items, and its potential applicability even when the appendix is not visualized on ultrasonography make the BIDIAP index a promising tool for supporting clinical decision-making in routine pediatric emergency practice.

BackgroundSecondhand smoke (SHS) exposure remains a major public health concern among adolescents, particularly in low- and middle-income countries. Evidence from Zambia is limited, despite increasing tobacco use and existing tobacco control policies. This study examined the prevalence and correlates of SHS exposure among adolescents in Zambia. MethodsWe analyzed data from the 2021 Zambia Global Youth Tobacco Survey (GYTS), a nationally representative, school-based survey. The sample included 6,499 adolescents aged 11-17 years enrolled in grades 7-9. The primary outcome was any SHS exposure, defined as exposure to tobacco smoke at home, school, enclosed public places, or outdoor public places. Weighted prevalence estimates were calculated, and multivariable logistic regression was used to identify factors associated with SHS exposure, adjusting for demographic, social, environmental, and socioeconomic variables. ResultsOverall, 66.0% of adolescents reported exposure to SHS. Adolescents living with a parent or guardian who smoked had nearly three times higher odds of SHS exposure (adjusted odds ratio [AOR] = 2.76; 95% CI: 2.12-3.62; p < 0.001). Having friends who smoked tobacco (AOR = 1.86; 95% CI: 1.52-2.30; p < 0.001) and seeing teachers smoking at school (AOR = 1.88; 95% CI: 1.40-2.56; p < 0.001) were also significant predictors. Media exposure was important: seeing people use tobacco on television (AOR = 1.88; 95% CI: 1.63-2.17; p < 0.001) and exposure to tobacco advertisements (AOR = 1.38; 95% CI: 1.14-1.67; p = 0.001) increased odds of SHS exposure. Adolescents who had smoked cigarettes had higher odds of exposure (AOR = 2.80; 95% CI: 1.70-4.67; p < 0.001), as did those intending to use tobacco in the next five years (AOR = 1.64; 95% CI: 1.21-2.24; p = 0.002). Age, sex, and grade level were not independently associated with SHS exposure. ConclusionsSHS exposure among adolescents in Zambia is widespread and is largely driven by household smoking, peer influence, school environments, and media exposure. Strengthening enforcement of smoke-free policies, promoting smoke-free homes, and addressing social and media influences are critical to reducing adolescent SHS exposure.

IntroductionTobacco smoking among school-going adolescents poses a major global public health challenge, contributing significantly to future disease burden. Understanding the prevalence and determinants of cigarette smoking in this group is critical for effective interventions. MethodsThis study analyzed data from the Global Youth Tobacco Surveys collected between 2001 and 2021, covering 439, 322 school-going adolescents aged 11 to 19 across 45 African countries. Descriptive statistics estimated smoking prevalence by age, sex, school grade, country, and survey year. Predictive modelling identified independent correlates of current cigarette smoking under complex two-stage cluster sampling. ResultsOverall, 23.8% (95% CI: 20.20-27.57) of adolescents reported cigarette smoking. Prevalence increased with age, rising from 9.5% at 12 years to 22.4% at 18 years. Boys smoked more than girls (14.0% vs. 7.3%). Smoking varied widely across countries, with the highest rates in Burkina Faso 48.9%, and South Africa (18.9%), and the lowest in Angola (1.5%, 95% CI: 0.86-2.13), Eritrea (2.1%). Use of other tobacco products strongly increased the prevalence of cigarette smoking for smokeless chew (35%, 95% CI: 29.6-40.3). Being taught in school about the effects of smoking showed protective effects, while ownership of tobacco-branded items increased smoking likelihood (17.8%, 95% CI: 17.52-18.13). Smoking prevalence declined over time, with lowest rates in recent years (3.5% in 2020). ConclusionCigarette smoking among school-going adolescents in Africa is a growing public health concern influenced by factors such as age, gender, country, behavior, and media exposure. Urgent, youth-focused tobacco control strategies especially targeting males and older teens are needed. Strengthening school-based education and implementing tobacco control policies among students can help reduce smoking rates. These findings offer vital evidence to inform global tobacco control efforts within the African context